The Journal of Neuroscience, July 12, 2006, ():
Intersubunit Interactions in EAAT4 Glutamate Transporters
J. Neurosci. Torres-Salazar and Fahlke
26: 7513
Supplemental data
Files in this Data Supplement:
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Supplemental Figure 1. R501C changes the substrate sensitivity of EAAT4. A,B, Representative current responses to a voltage steps to +125 mV from cells transfected with WT (A) and R501C (B) EAAT4 without application of substrate (dotted line), in the presence of 1 mM serine (dashed line) and 1 mM glutamate (solid line), respectively. C, D, Voltage dependence of mean current amplitudes ± SEM (n = 5;C and 6;D) upon the application of serine (?), glutamate (?) and without any of these two substrates (?). WT current amplitudes at 1 mM serine and R501C current amplitudes at 1 mM glutamate were not different from control values without substrate (p>0.05 for WT and p>0.1 for R501C EAAT4, respectively).
