Epidermal Growth Factor Receptor Activation: An Upstream Signal for Transition of Quiescent Astrocytes into Reactive Astrocytes after Neural Injury
J. Neurosci. Liu et al.
26: 7532
Supplemental data
Files in this Data Supplement:
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Table S1: Accession numbers in the website for the CEL files of gene microarrays for control astrocytes and astrocytes treated with EGF for 4 hours and 12 hours.
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Table S4: Functional annotation of EGFR pathway-regulated genes.
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Figure S1: Real time RT-PCR detected the fold changes in gene expression levels between EGF treated astrocytes and control astrocytes.
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Figure S2: Temporal pattern diagram of the expression of EGFR pathway-regulated genes. The expression of EGFR pathway-regulated genes had different temporal patterns: increased or decreased at 4 hours but returned towards control values at 12 hours (black); increased or decreased continuously over 12 hours (red); increased or decreased to a plateau after 4 hours (green); did not change at 4 hours but increased or decreased at 12 hours (blue). The number at each line is the number of genes in each pattern listed in table S3.
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Video S1: Morphologic changes of astrocytes stimulated by EGF.