The Journal of Neuroscience, September 20, 2006, ():
A Specific Survival Response in Dopamine Neurons at Most Risk in Parkinson's Disease
J. Neurosci. Murase and McKay
26: 9750
Supplemental data
Files in this Data Supplement:
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Supplemental Figure 1. FGF-20 promotes survival and DA function in calbindin- DA neurons. In ventral midbrain, there are at least two types of DA neurons, calbindin+ (orange) and calbindin- (blue), each of which projects to a distinct area in striatum (adopted from Gerfen, 2004 (Gerfen, 2004)). Calbindin+ cells are enriched in ventral tegmental area (VTA) and dorsal tier of SNpc, whereas calbindin- cell are enriched in ventral tier of SNpc. The neural activity is regulated by D2 autoreceptor (pink) in these cells. These neurons are known to express different levels of DAT (green) and VMAT2 (black). In this study, we showed that calbindin- DA neurons in the ventral tier of SNpc expressed high levels of FGFR1 (purple) compared to calbindin+ DA neurons in the dorsal region. FGF-20 (yellow) promotes not only survival of calbindin- DA neurons but also the vesicle DA (red) release through activation of TH (brown). Note that calbindin- DA neurons are at most risk in PD.
