The Journal of Neuroscience, October 4, 2006, ():
Functional Role of GABAergic Innervation of the Cochlea: Phenotypic Analysis of Mice Lacking GABAA Receptor Subunits 
1, 2, 5, 6, 
2, 3, or 
J. Neurosci. Maison et al.
26: 10315
Supplemental data
Files in this Data Supplement:
- supplemental material
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Figure S1: Schematic of the organ of Corti showing one row of inner hair cells (IHCs), three rows of outer hair cells (OHCs), a cochlear nerve afferent fiber contacting an inner hair cell, an efferent fiber from the medial olivocochlear (MOC) system contacting all three rows of OHCs and an efferent fiber from the lateral olivocochlear (LOC) system contacting and IHC and the dendrite of a cochlear nerve fiber.
- supplemental material
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Figure S2: Four GABA(A) mutant lines, α1, α2, α6 and δ, showed no abnormalities in cochlear function. Group mean thresholds (+/- SEM) for homozygous nulls (open symbols) are compared in each panel to wildtype littermates (filled symbols): all animals were tested at 6 weeks. The top row (Panels A-D) shows results of ABR tests; the bottom row (Panels E-H) shows results of the concurrent DPOAE tests (with threshold data plotted at the frequency corresponding to f2, the higher frequency of the 2-tone stimulus complex). Group sizes for each of the knockout lines are shown in Table 1. Key in Panel A applies to all panels.
- supplemental material
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Figure S3: OHC efferent function was unaffected in three other mutant lines: α1, α2 and δ (in addition to those shown in Figure 3). Efferent function was assessed by measuring DPOAE suppression caused by efferent-bundle shocks, normalized as described in Methods. Panels A, B, C: group mean data (+/- SEM) for suppression magnitude for each of the 6 test frequencies in the mutant indicated. Numbers of animals tested in each genotype from each strain are in Table 1.
