The Journal of Neuroscience, October 11, 2006, ():
p25/Cyclin-Dependent Kinase 5 Induces Production and Intraneuronal Accumulation of Amyloid 
In Vivo
J. Neurosci. Cruz et al.
26: 10536
Supplemental data
Files in this Data Supplement:
- supplemental material
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Figure S1. APP and CTFs from WT and CK-p25 mice induced and non-induced for 2 weeks are similar, as revealed by immunoblot analyses of RIPA-soluble forebrain extracts.
- supplemental material
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Figure S2. Enhanced BACE1 and β-secretase processing of APP in p25 Tg mice induced for 5 weeks. Increased levels of BACE1 expression and C-terminal APP fragments was revealed by immunoblot analyses of RIPA-soluble forebrain extracts from 5 week induced CK-p25 mice as compared to WT controls. Full length APP levels were unchanged. Quantification of bands from WT (n=3) and CK-p25 Tg (n=4) mice was statistically significant by Student’s t-test (P<0.05) for both BACE1 and APP C-terminal fragments.
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