The Journal of Neuroscience, November 1, 2006, ():
An Acute Effect of Neuregulin 1
to Suppress 
7-Containing Nicotinic Acetylcholine Receptors in Hippocampal Interneurons
J. Neurosci. Chang and Fischbach
26: 11295
Supplemental data
Files in this Data Supplement:
- supplemental material
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Figure S1. I-V plots for the (A) fast, α7 and the (B) slow, non-α7 currents induced by ACh in SR interneurons. The I-V curves of both types of current indicated inward rectification.
- supplemental material
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Figure S2. Averaged slow, non-α7 current amplitudes (% of T = 0; mean ± SEM; n = 6 cells) plotted vs. time (min) in controls and in the presence of NRG 1β (5 nM). NRG 1β did not affect the slow component of the biphasic responses.
- supplemental material
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Figure S3. PTP inhibitor orthovanadate (1 mM) eliminated the recovery (sag back) of ACh currents during NRG 1β (5nM) application. A, Averaged fast monophasic current amplitudes (% of T = 0; mean ± SEM; n = 6 cells) plotted vs. time (min) in controls, in the presence of orthovanadate, and in the presence of orthovanadate + NRG 1β. Note the small but consistent reduction in current amplitude in the presence of orthovanadate. B, Averaged fast α7 component of biphasic currents (% of T = 0; mean ± SEM; n = 6 cells) plotted vs. time (min) in controls, in the presence of orthovanadate, and in the presence of orthovanadate + NRG 1β. Suppression by orthovanadate is not as consistent in this series of measurements as that was shown in A.
