The Journal of Neuroscience, November 1, 2006, ():
Increased Citrullination of Histone H3 in Multiple Sclerosis Brain and Animal Models of Demyelination: A Role for Tumor Necrosis Factor-Induced Peptidylarginine Deiminase 4 Translocation
J. Neurosci. Mastronardi et al.
26: 11387
Supplemental data
Files in this Data Supplement:
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Supplemental Table
- supplemental material
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Figure 1) Luxol Fast Blue histology of Normal white matter and MS NAWM. Uniform myelin white matter luxol fast blue (blue stain) in MS cortical white matter. Hematoxylin counter staining of nuclei indicates lack of perivascular infiltration, The numbers in the bottom right hand corner correspond to the individuals (HSB#) in Table II. (200x magnification).
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Figure 2)Astrocytosis and lack of microglial infiltration in the analyzed samples (A) Immunohistochemical labeling of a representative staining from normal white matter from controls and MS patients with anti-GFAP (brown) antibodies to detect astrocytes. The positive control is MS lesion white matter, The numbers in the bottom right hand corner correspond to the individuals (HSB#) in Table II. (200x magnification). (B) Immunohistochemical labeling of a representative staining from normal white matter from controls and MS patients with anti- CD68 (brown) antibodies to detect infiltrating microglia. The positive control is a human tonsil, The numbers in the bottom right hand corner correspond to the individuals (HSB#) in Table II. (200x magnification).
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Figure 3) Immunohistochemical labeling of Normal white matter and MS NAWM with anti-CD3 and anti-CD8. (A) Anti-CD3 was used to detect infiltrating lymphocytes in tissue sections of cortical white matter. The positive control was human tonsil, The numbers in the bottom right hand corner correspond to the individuals (HSB#) in Table II. (200x magnification). (B) Anti-CD8 was used to detect infiltrating activated lymphocytes in tissue sections of cortical white matter. The positive control was human tonsil, The numbers in the bottom right hand corner correspond to the individuals (HSB#) in Table II. (200x magnification).
