The Journal of Neuroscience, February 1, 2006, ():
The Dopaminergic Midbrain Participates in Human Episodic Memory Formation: Evidence from Genetic Imaging
J. Neurosci. Schott et al.
26: 1407
Supplemental data
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Supplemental material
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Figure 7: Session structure and trial timings. Responses in the test phase were scored and used for classification of study items as hits (subsequently remembered) and misses (subsequently forgotten), separately for deeply and shallowly studied items.
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Figure 8: Effects of the COMT Val108/158Met polymorphism on fMRI correlates of level of processing (deep vs. shallow study). Compared to Met homozygous subjects, Val homozygous subjects showed relatively higher activation of the right prefrontal cortex (left panel) and of the left fusiform gyrus (right panel).
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Figure 9: Controls for immunohistochemistry. A: A dense pattern of DAT1-immunoreactive fibers was observed in sections of the human striatum. B: Control section from the striatum without primary antibody. No unspecific immunoreactivity was observed to the secondary antibody alone.
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Figure 10: Model for a possible mechanism of DAT1-VNTR-related variability of memory-related midbrain activity over time. Presumably, 9-repeat carriers with lower DAT1 expression have lower average levels of both tonic and phasic midbrain activity (dashed line) as compared to 10-repeat homozygous subjects. They might thus have required a higher relative increase in midbrain activity to reach a "threshold" level required to promote successful episodic encoding of stimuli in the hippocampus. x-axis: time; y-axis: midbrain activity.
