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The Journal of Neuroscience, February 1, 2006, ():

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The Androgen 5{alpha}-Dihydrotestosterone and Its Metabolite 5{alpha}-Androstan-3beta, 17beta-Diol Inhibit the Hypothalamo–Pituitary–Adrenal Response to Stress by Acting through Estrogen Receptor beta-Expressing Neurons in the Hypothalamus
J. Neurosci. Lund et al. 26: 1448

Supplemental data

Files in this Data Supplement:

  • supplemental material - Supplemental Figure. Diagram showing the pathway for metabolism of testosterone and the steroid metabolizing enzymes necessary for conversion . In this pathway, estrogen is derived from aromatase and DHT is derived from testosterone through the action of 5α-reductase. 3α- and 3β-diol are derived from DHT through the activity of the enzymes 3α-hydroxysteroid dehydrogenase (3αHSD) 3βHSD and 17βHSD. The levels of 3β-diol is regulated by the expression of CYP7B which inactivates 3β-diol by converting it to 5α-androstane-3β,6α,17β-triol and to 5α-androstane-3β,7α,17β-triol (6α and 7α triols).



This Article
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Citing Articles
Right arrow Citing Articles via Web of Science (49)

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