The Journal of Neuroscience, February 1, 2006, ():
The Dopamine D3 Receptor Is Part of a Homeostatic Pathway Regulating Ethanol Consumption
J. Neurosci. Jeanblanc et al.
26: 1457
Supplemental data
Files in this Data Supplement:
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Supplemental Figure 1. Model - RACK1, BDNF and D3R are part of a homeostatic pathway that controls ethanol intake. (1) Acute ethanol exposure results in the translocation of RACK1 to the nucleus (Ron et al., 2000). Nuclear RACK1 mediates an increase in BDNF expression (McGough et al., 2004). Increasing the protein levels of RACK1 via Tat-RACK1 transduction also results in elevated levels of BDNF (McGough et al., 2004). (2) Increased BDNF expression leads to an increase in secreted BDNF protein. (3) Secreted BDNF activates the TrkB receptor and downstream signaling cascade, resulting in increased D3R expression. (4) Activation of the D3R by dopamine reduces ethanol intake.
