The Journal of Neuroscience, December 20, 2006, ():
Subcutaneous Nogo Receptor Removes Brain Amyloid-ß and Improves Spatial Memory in Alzheimer's Transgenic Mice
J. Neurosci. Park et al.
26: 13279
Supplemental Data
Files in this Data Supplement:
- supplemental material
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Supplemental Figure S1. Visible platform testing is not altered by NgR(310)ecto-Fc treatment.
APPswe/PSEN-1ΔE9 transgenic mice were treated subcutaneously with 0.27 mg/kg/d
NgR(310)ecto-Fc or IgG from age 7 months to 10 months. The escape latency to reach a
visible platform was measured at the end of the treatment period. Mean + sem from n=7-9 mice per group.
- supplemental material
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Supplemental Figure S2. NgR(310)ecto-Fc treatment improves the process of learning in radial arm water maze by transgenic mice .
Data from the same experiment as Figure 5d are plotted to indicate the number of errors during swim trials 1-5 (A), 1-10 (B), 11-20 (C) or during all trials 1-30 (D). Subcutaneous treatment with NgR(310)ecto-Fc beginning at month 7 improved the performance APPswe/PSEN-1∆E9 mice tested for 30 trials at age 9 months or 10 months.. **,significantly less than IgG group at the same age, P < 0.02, ANOVA.
