The Journal of Neuroscience, February 8, 2006, ():
Small-Conductance Ca2+-Activated K+ Channel Type 2 (SK2) Modulates Hippocampal Learning, Memory, and Synaptic Plasticity
J. Neurosci. Hammond et al.
26: 1844
Supplemental data
Files in this Data Supplement:
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Supplementary Figure 1. SK2 overexpression impairs learning and memory in the Morris water maze. In this experiment, naïve male SK2+/T (n = 12) and WT littermate mice (n = 6) were trained in the hidden platform water maze task for 6 days (4 trials/day). (a) SK2 overexpression significantly impaired acquisition of the hippocampal-dependent water maze task as assessed by CDT measures (genotype effect (|*bital*|F|*eital*|(1,22) = 4.78, |*bital*|P|*eital*| < 0.05). SK2+/T and WT mice exhibited similar CDT measures on the first day of training, suggesting that the differences between SK2+/T and WT mice in CDT scores (in Fig. 6) on the first day of hidden platform training may be due to prior experience in the visible platform task. (b) SK2+/T mice exhibited significantly less accurate platform search behavior than WT mice during the final probe test given 24 hr after the last training trial (* |*bital*|P|*eital*| < 0.05, Student’s |*bital*|t|*eital*|-test).
