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The Journal of Neuroscience, February 8, 2006, ():

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Cell-Specific Repressor or Enhancer Activities of Deaf-1 at a Serotonin 1A Receptor Gene Polymorphism
J. Neurosci. Czesak et al. 26: 1864

Supplemental data

Files in this Data Supplement:

• supplemental material - Supplemental Figure 1: Model of Deaf-1-mediated transcriptional regulation of the 5-HT1A promoter Deaf-1 binds to a minimal consensus TTCG Deaf-1 site to repress 5-HT1A receptor gene transcription in pre-synaptic raphe cells, while it enhances transcription in post-synaptic 5-HT1A-expressing cells. Hes5 acts as a transcriptional repressor in a cell-independent manner. Cell-specific transcriptional repression and enhancement of the 5-HT1A promoter are intrinsic activities of Deaf-1 that require histone deacetylase (HDAC) activation and are abolished when the C(-1019)G polymorphism is present.

This Article Abstract Full Text Submit an eLetter Services Email this article to a friend Alert me to new issues of the journal Citing Articles Citing Articles via Web of Science (23)

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