The Journal of Neuroscience, February 15, 2006, ():
Repetitive Transcranial Magnetic Stimulation-Induced Changes in Sensorimotor Coupling Parallel Improvements of Somatosensation in Humans
J. Neurosci. Pleger et al.
26: 1945
Supplemental data
Files in this Data Supplement:
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Supplementary Table 1 Cortical regions of both hemispheres which are involved in the frequency discrimination: Shown are the MNI coordinates and the T-scores of the peak voxels of each region contra- and ipsilateral to the stimulated right index finger.
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Supplementary Figure 1 DCM model 2-5. For each subject, three time series (‘A’, ‘C’ and ‘D’, for spatial distribution see inset of Fig. 4) were embedded into 5 alternative DCMs (see Fig. 6b for structure of model 1) to evaluate the individual coupling strengths of intrinsic connections and contextual variables. Using Bayesian model selection (Penny et al., 2004), we ranked models according to their evidence across subjects: model 1 vs. 2 (5:2) – 1 vs. 3 (9:0) – 1 vs. 4 (9:0) – 1 vs. 5 (7:0).
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Supplementary Figure 2 Recovery of cortical and psychophysical changes. The box plot shows cortical signals within peak voxel of SI (area 3b) (grey boxes) and frequency discrimination abilities (white boxes) of 3 subjects pre, post and 120 minutes after rTMS application. The error bars indicate the standard error. Note that both, cortical and psychophysical changes, recovered 2 hours after rTMS (frequency discrimination (percent correct): pre 83.33 +/- 3.29 %, post 86.66 +/- 2.18 %, recovery 81.29 +/- 4.48 %; fMRI signal changes (relative to global mean brain signal) within individual SI peak voxels: pre 1.35 +/- 0.44 %, post 2.22 +/- 0.54 %, recovery 1.4 +/- 0.4 %).
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Supplementary Figure 3 Spatial selectivity of the rTMS effects. Top: The box plots shows (a) frequency discrimination abilities (grey boxes) and (b) cortical signals within peak voxel of SI (area 3b) (white boxes) of 3 subjects pre and post fMRI while testing the index finger of the left hand with rTMS still applied over the right index finger representation (left SI). The error bars indicate the standard error. Note that the frequency discrimination ability (a) and the cortical signals (b) remained unchanged (frequency discrimination (percent correct): pre 76.97 +/- 7.7 %, post 75.82 +/- 5 %; fMRI signal changes within SI peak voxel: pre 2.11 +/- 0.76 %, post 1.96 +/- 1.05 %). Bottom: Shown are (a) frequency discrimination abilities (grey boxes) and (b) cortical signals within peak voxel of SI (white boxes) of the same 3 subjects pre and post fMRI while testing the index finger of the right hand with rTMS applied over the right index finger representation (left SI) (frequency discrimination (percent correct): pre 81.95 +/- 4.94 %, post 87.14 +/- 2.47 %; fMRI signal changes within SI: pre 1.63 +/- 0.59 %, post 2.14 +/- 0.79 %).
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Supplementary Figure 4 Control for tactile sensations elicited at the scalp. The box plots shows (a) frequency discrimination abilities (grey boxes) and (b) cortical signals within peak voxel of SI (area 3b) (white boxes) of 3 subjects pre and post fMRI while testing the index finger of the left hand with rTMS applied to the left superior parietal cortex. The error bars indicate the standard error. Note that the frequency discrimination ability (a) and the cortical signals (b) remained unchanged (frequency discrimination (percent correct): pre 69.86 +/- 5.85 %, post 70 +/- 5.4 %; fMRI signal changes within SI peak voxel: pre 2.02 +/- 1.27 %, post 1.96 +/- 1.2 %).
