The Journal of Neuroscience, March 1, 2006, ():
Protein Kinase A Regulates the Sensitivity of Spinal Commissural Axon Turning to Netrin-1 But Does Not Switch between Chemoattraction and Chemorepulsion
J. Neurosci. Moore and Kennedy
26: 2419
Supplemental data
Files in this Data Supplement:
- supplemental material
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Supplementary Figure. Model: Activating PKA recruits DCC to the growth cone plasma membrane, increasing the sensitivity of commissural axon turning toward a source of netrin-1. (A) Increasing the concentration of intracellular of cAMP increases the range over which commissural axons turn to a source of netrin-1. (B) Activating adenylate cyclase (AC) increases cytosolic cAMP concentration, activating PKA, and triggering the recruitment of DCC to the growth cone plasma membrane, thereby increasing the sensitivity of the growth cone to netrin-1. Netrin-1 binding to DCC directs cytoskeletal rearrangements underlying chemoattraction, independent of downstream activation of PKA.
