The Journal of Neuroscience, March 21, 2007, ():
Lhx6 Activity Is Required for the Normal Migration and Specification of Cortical Interneuron Subtypes
J. Neurosci. Liodis et al.
27: 3078
Supplemental Data
Files in this Data Supplement:
- supplemental material
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Supplementary Figure 1. Cortical layer formation does not depend on Lhx6 activity. (A-D), cresyl violet staining of brain sections from Lhx6- heterozygous (A and C) and homozygous (B and D) 2 week-old animals. No obvious differences in cortical histology were detected between control and Lhx6-deficient animals. (E-H), in situ hybridisation of brain sections from heterozygous (E and G) and homozygous (F and H) animals with riboprobes specific for Cux2 (E and F) and Er81 (G and H).
- supplemental material
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Supplementary Figure 2. Migratory deficit of Lhx6-deficient MGE cells. (A) diagrammatic presentation of DiI labelling of MGE cells in coronal sections for E13.5-14.5 mouse embryo brain. In slices from heterozygous embryos (B), a large number of fluorescent cells were observed in the lateral cortex after 48 hours in culture. In contrast, no fluorescent cells were present in the cortex of mutant slices (C). mge, medial ganglionic eminence; ncx, neocortex.
