The Journal of Neuroscience, April 18, 2007, ():
Suppressed Neuronal Activity and Concurrent Arteriolar Vasoconstriction May Explain Negative Blood Oxygenation Level-Dependent Signal
J. Neurosci. Devor et al.
27: 4452
Supplemental Data
Files in this Data Supplement:
- supplemental material
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Supplementary Figure 1. Peak positive (upper panel) and peak negative (lower panel) HbT (A) and Hb (B) signal change as a function of distance from the center. Data from 4 animals are superimposed (circles, squares, upward triangles, downward triangles). Note that the sign of Hb signal change is opposite to that of HbO and HbT, negative in the center and positive in the surround.
- supplemental material
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Supplementary Figure 2. Laminar array recordings of MUA and LFP from the second animal. Top: Averaged MUA response from the center (left) and the surround (right). Left and right columns are plotted on the same scale. The response to the first of the 3 stimuli in a train is shown. Each trace represents a recording from one single electrode in the array. Corresponding cortical depth is indicated on the left. The top electrode was positioned on the brain surface (depth = 0). Recordings down to 1500 μm are shown. 500 stimulus trials were averaged. Electrical stimulus artifact is covered by gray rectangles. Arrows denote stimulus onset. Bottom: Averaged LFP response from the center (left) and the surround (right). Conventions are the same as for MUA.
- supplemental material
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Supplementary Figure 3. Arteriolar vasodilation and vasoconstriction as a function of distance from the center of evoked neuronal response. An average of arteriolar diameter changes (Δd/d) within 1 mm from the center of neuronal response (blue), in a 1-1.5 mm ring around the center (red), in a 1.5-2 mm ring around the center (green), and at distances >2 mm (magenta) for all 216 measured locations. Dilation and constriction are plotted upward and downward respectively. Note that vasoconstriction reached peak faster further away from the center of neuronal activity (red arrows).
