The Journal of Neuroscience, May 23, 2007, ():
Nicotinic 
7 Receptors as a New Target for Treatment of Cannabis Abuse
J. Neurosci. Solinas et al.
27: 5615
Supplemental Data
Files in this Data Supplement:
- supplemental material
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Supplemental Fig.1. Histological verification of microdialysis probe location. Vertical lines indicate the placement of microdialysis probes within brain sections (as modified from Paxinos & Watson, 1998) in the shell of the nucleus accumbens. Numbers beside each plate represent distance from bregma. Data from 2 rats were discarded because of incorrect placement.
- supplemental material
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Supplemental Fig.2. A 5.6 mg/kg dose of MLA is necessary to reduce the discriminative effects of THC when a 120 min pre-treatment time is used. Effects of 3 and 5.6 mg/kg of MLA on the discrimination of the 3 mg/kg training dose of THC as a function of the pretreatment time (45 and 120 min). The dotted line represents the level of THC-lever selection after administration of the training 3 mg/kg training dose of THC. Results represent the meansąSEM from 8 rats. Two-way ANOVA statistical analysis for repeated measures demonstrated significant effect of time F(1,7)= 27.917, p<0.01 and significant Dose X Time interaction F(1,7)= 5.83, p<0.05 *, p<0.05 compared to the corresponding time point by Bonferroni post-hoc test.
- supplemental material
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Supplemental Fig.3. A 3 mg/kg dose of DHBE blocks the potentiation of THC discrimination induced by 0.1 mg/kg of nicotine. Effects of 3 mg/kg of DHBE on nicotine-induced potentiation of THC discrimination, an effect that we had previously caractherized (Solinas et al., 2007). Ordinates, upper panel: % THC-lever selection; lower panel: rates of responding. Abscissae: dose of THC. Results represent the meansąSEM from 9-11 rats. Two-way ANOVA statistical analysis for repeated measures demonstrated significant effect of treatment F(3,111)=19.63, p=0.0002.
