The Journal of Neuroscience, June 6, 2007, ():
Dendritic Pathology in Prion Disease Starts at the Synaptic Spine
J. Neurosci. Fuhrmann et al.
27: 6224
Supplemental Data
Files in this Data Supplement:
- supplemental material
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Supplementary Figure 1. Spine density and dendritic integrity of Scrapie-infected YFP-H x PrP% control mice. (A) Overview of an apical dendrite from a YFP-H x PrP% mouse at 210 dpi imaged at zero and 120 minutes. (B) Representative time-lapse images of a dendritic branch from (A). Blue arrows exemplarily indicate spines that were stable over 120 minutes. Spine density and dendritic integrity was unchanged during 120 minutes of imaging. (C) Spine density of Scrapie-infected YFP-H x PrP% animals at 210 dpi and non-infected YFP-H control animals were not significantly different (n=2 animals, P = 0.6). (D) Time lapse images of an apical dendrite from a YFP-H x PrP% mouse from 99 to 133 dpi. Blue arrows indicate stable spines and the green arrow points at a gained spine. (E) Spine density of the YFP-H x PrP% mouse in (D) from 99 to 133 dpi. The spine density remains constant. Scale bar: (A) 10 µm; (B, D) 2 µm.
