The Journal of Neuroscience, July 4, 2007, ():
Neurovascular Protection by Ischemic Tolerance: Role of Nitric Oxide and Reactive Oxygen Species
J. Neurosci. Kunz et al.
27: 7083
Supplemental Data
Files in this Data Supplement:
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Supplemental Table
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Supplemental Figure 1: NO byproducts (nitrite and nitrate; NOx) in parietal cortex homogenates 8 hrs following systemic administration of LPS. NOx were measured using a fluorimetric assay (Misko et. al, 1998). LPS increased NOx, and the effect was blocked by AG and not observed in iNOS null mice.
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Supplemental Figure 2: Effect of MCAO on the increase in CBF produced by topical superfusion with adenosine (400µM) min in nox2+/+ and -/- mice. p>0.05, analysis of variance and Newman-Keuls test; N=5-6/group.
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Supplemental Figure 3: Effect of FeTPPS on the increase in 3-NT immunoreactivity produced by LPS. LPS increases 3-NT immunoreactivity compared to vehicle treated mice (A, B). FeTPPS attenuated LPS-induced 3-NT immunoreactivity (C) (LPS: 32±4; LPS+FeTPPS: 21±1; RFU; p<0.05; n=5/group). Asterisks in A, B, and C indicate the pial surface and the arrows point to penetrating arterioles. *p<0.05 from LPS; Student’s t-test; N=5/group.
