The Journal of Neuroscience, July 11, 2007, ():
BMPR1a Signaling Determines Numbers of Oligodendrocytes and Calbindin-Expressing Interneurons in the Cortex
J. Neurosci. Samanta et al.
27: 7397
Supplemental Data
Files in this Data Supplement:
- supplemental material
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Supplementary Figure 1: Mutation of BMPR1a has no effect on the overall number of neurons in the dorsal cortex. Neurons were labeled with nissl stain and the nuclei were counterstained with DAPI in coronal sections of P0 (A-F) and P20 (G-L) wildtype and knockout forebrains.
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Supplementary Figure 2: Mutation of BMPR1a produces no significant change in oligodendroglial progenitor numbers and does not affect myelination. Immunohistochemistry for PDGFRα (A-B) and NG2 (C-F) was performed in the dorsal forebrains of P0 and P20 mice. KO and WT forebrains had similar numbers of progenitor cells at both P0 and P20. (G, H) Pan axonal neurofilament marker colocalized with PLP myelin in the corpus callosum. KO= knock-out; WT= wildtype; n=5.
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Supplementary Figure 3: Olig1 expressing neural stem cells produce Astrocytes.
Immunohistochemistry in P4 Olig1-cre/R26 mice shows co-localization of β-galactosidase with GFAP (A-C) in the forebrain.
