The Journal of Neuroscience, July 11, 2007, ():
Nuclear Localization of Ataxin-3 Is Required for the Manifestation of Symptoms in SCA3: In Vivo Evidence
J. Neurosci. Bichelmeier et al.
27: 7418
Supplemental Data
Files in this Data Supplement:
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Supplementary Figure: Hearing functions of transgenic SCA3 mice and controls
In 5-6 weeks old transgenic mice with 70 CAG repeats (line 70.61) and negative littermates as controls, the hearing functions was analyzed with different methods. (A) Auditory brainstem responses (ABR) thresholds on click stimuli, mean and standard deviations. The thresholds represent typical hearing thresholds for mice on click stimuli. (B) ABR thresholds as a function of audio frequency were similar for wild type and transgenic mice. (C) Distortion product of the otoacoustic emissions (DPOAE) thresholds (dB SPL f1), a measure for the function and efferent control of the electro-motile cochlear outer hair cells. (D) DPOAE maximum amplitude at F2=11.3 kHz, giving a rating for the force and integrity of the outer hair cell function. DPOAE threshold function and maximum amplitude were similar for both wt and tg mice.
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