The Journal of Neuroscience, July 18, 2007, ():
Annonacin, a Natural Mitochondrial Complex I Inhibitor, Causes Tau Pathology in Cultured Neurons
J. Neurosci. Escobar-Khondiker et al.
27: 7827
Supplemental Data
Files in this Data Supplement:
- supplemental material
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Supplemental Movie 1. Time-lapse video-microscopy to show movements of mitotracker-stained mitochondria (green) in a control neuron.
Images were taken at 10 min. intervals over a period of 140 min. Both anterograde and retrograde movements are seen without evident predilection for either direction.
- supplemental material
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Supplemental Movie 2. Time-lapse video-microscopy to show movements of mitotracker-stained mitochondria (green) in an annonacin-treated neuron.
Images were taken at 10 min. intervals over a period of 140 min. starting 1 min. after addition of 50 nM annonacin to the culture medium. In contrast to control neurons, only the retrograde movement of mitochondria from neurites to the soma was seen in annonacin-treated neurons.
