The Journal of Neuroscience, January 17, 2007, ():
Metastability of Active CA3 Networks
J. Neurosci. Sasaki et al.
27: 517
Supplemental Data
Files in this Data Supplement:
- supplemental material
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Supplemental Movie 1 Spontaneous activity of CA3 neurons in a slice loaded with Oregon Green 488 BAPTA-1. Images were captured by a Nipkow spinning disk confocal microscope at 10 frames /s. Data are the same as shown in Fig. 1C. The shadow in the top-right part of the field is a patch-clamp electrode.
- supplemental material
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Supplemental Movie 2 Time course of spontaneous activity, network states, and potential energy function. Map of active cells, PC trajectory, and potential energy (U) at the time indicated in the rasterplot (top) are displayed in bottom panels. For details, see figures 3, 4, and 11.
- supplemental material
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Supplemental Figure 1 Effect of the bin size on trajectory-like cluster structures in the PC space. The same rasterplot as Fig. 2A was binned with different time windows (1-50 s) and its spatiotemporal pattern of spontaneous activity was converted into a two-dimensional PC space (left). The contribution ratios were compared to those in ISI-shuffled (middle) and event-exchanged surrogates (right). For details, see text.
- supplemental material
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Supplemental Figure 2 Network state transitions occur even in culture medium. A, B, Contribution rates were significantly higher than those of ISI-shuffled (1) and event-exchanged surrogates (2). Data were divided into the optimal number of clusters, determined by the Dunn index (3), with the fuzzy K-means algorithm (4). Time course of a change in network states (5) revealed that states tended to shift up to other states and drift away from the original state. Similar results were obtained in all three movies.
