The Journal of Neuroscience, August 8, 2007, ():
Drosophila Overexpressing Parkin R275W Mutant Exhibits Dopaminergic Neuron Degeneration and Mitochondrial Abnormalities
J. Neurosci. Wang et al.
27: 8563
Supplemental Data
Files in this Data Supplement:
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Supplemental Table
- supplemental material
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Supplemental Figure S1. Mitochondrial abnormalities in R275W mutant flies (A) TEM images showing pleiomorphic mitochondrial pathologies in the indirect flight muscles of 20 day-old flies expressing R275W mutant parkin. (Genotype: 24B-Gal4/+; UAS-hParkin/+)
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Supplemental Figure S2. Co-expression of wild-type parkin and R275W mutant mitigates the loss of PPL1 neurons (A) Representative confocal microscopy images showing TH-positive (red) dopaminergic neurons in the PPL1 cluster of 20 day-old transgenic flies expressing wild-type (WT) or R275W parkin alone (Genotype: Ddc-Gal4/+; UAS-hParkin/+) or in combination (Genotype: WT, Ddc-Gal4/ R275W, Ddc-Gal4), as indicated (B) Bar-graph showing the number of dopaminergic (DA) neurons in different clusters of the various fly species described above, as indicated (**P < 0.01, Student’s t-test, n=10).
