Figure 5.
Actively transporting axons labeled with BDA and examined with the electron microscope do not show extensive demyelination. A, A coronal cut through the lesion that illustrates the appearance of the spared rim of white matter. B–D, Asterisks indicate BDA filled axons that have mature looking myelin caudal to the injury (B, arrow) that is similar to that of control spinal cord (C, D). E, Axons in injured animals had a tendency for bigger G-ratios (mean, 0.71; R2 = 0.2) compared with controls (mean, 0.68; p = 0.06; R2 = 0.4). F, G-ratio correlates within internode length in control (R2 = 0.96) and injured (R2 = 0.81) animals. Scale bars: A, C, 300 μm; B, D, 2 μm. D, Dorsal.