Figure 8.
DMH NPY modulates satiation actions of peripheral CCK. A, Knockdown of DMH NPY expression enhanced CCK-induced feeding inhibition. VEH, Vehicle-treated rats; CCK, CCK-treated rats. n = 10 rats per group. *p < 0.05 compared with AAVshCTL/VEH, #p < 0.05 compared with AAVshNPY/VEH, and §p < 0.05 compared with AAVshCTL/CCK. B, Representative micrograph shows c-Fos-immunoreactive response to peripheral administration of CCK in the NTS and the AP. AAVshCTL/VEH, Vehicle-treated AAVshCTL rats; AAVshCTL/CCK, CCK-treated AAVshCTL rats; AAVshNPY/VEH, vehicle-treated AAVshNPY rats; AAVshNPY/CCK, CCK-treated AAVshNPY rats. C, Mean ± SEM c-Fos-positive neurons produced by peripheral administration of CCK. rNTS, Rostral NTS (−13.44); mNTS, medial NTS (−13.8); cNTS, caudal NTS (−14.28); also shown is AP (−13.8). n = 5 rats per group. *p < 0.05 compared with AAVshCTL/VEH, #p < 0.05 compared with AAVshNPY/VEH, and §p < 0.05 compared with AAVshCTL/CCK.