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Journal of Neuroscience, Vol 1, 27-39, Copyright © 1981 by Society for Neuroscience
Coexistence of neuronal and glial precursor cells in the cerebral ventricular zone of the fetal monkey: an ultrastructural immunoperoxidase analysis
P Levitt, ML Cooper and P Rakic
The cytological composition of the proliferative zones in the fetal monkey
occipital lobe was examined at the light and electron microscopic levels by
immunoperoxidase localization of glial fibrillary acid protein (GFA), a
protein that is present in astrocytes and radial glial cells but not
neurons. During the peak of neurogenesis at embryonic day 80, two distinct
classes of proliferative cells, GFA- positive and GFA-negative, are
intermixed in the ventricular and subventricular zones. Both cell types are
readily recognized in different phases of the mitotic cycle along the
ventricular surface. The results indicate that, contrary to prevailing
views, (1) glial and neuronal cell lines coexist within the fetal
proliferative zones and (2) the onset of glial phenotypic expression occurs
prior to the last cell division.
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