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Journal of Neuroscience, Vol 10, 169-175, Copyright © 1990 by Society for Neuroscience
A novel type of nicotinic receptor in the rat central nervous system characterized by patch-clamp techniques
C Mulle and JP Changeux
URA CNRS 0210 "Neurobiologie Moleculaire," Department des Biotechnologies, Institut Pasteur, Paris, France.
We present a functional characterization of a neuronal nicotinic receptor
in the CNS using patch-clamp techniques and a preparation of acutely
isolated neurons from the medial habenular nucleus of 10- to 20- d-old
rats. The salient pharmacological and electrophysiological properties of
this nicotinic response are (1) its association with a channel that is
relatively nonselective for cations and has a unitary conductance of 26.2
(+)+/- 5pS at room temperature; (2) its insensitivity to alpha-bungarotoxin
and to neuronal bungarotoxin; (3) its activation by the ganglionic
nicotinic agonists nicotine, 1,1- dimethyl-4-phenylpiperazinium and
cytisine and its blocking by several nicotinic antagonists, mecamylamine,
hexamethonium, d-tubocurarine, and dihydro-beta-erythroidine. The
combination of these properties has not been reported for any other known
type of nicotinic receptor.
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