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Journal of Neuroscience, Vol 10, 205-209, Copyright © 1990 by Society for Neuroscience

ARTICLE

The gene encoding peripheral myelin protein zero is located on mouse chromosome 1

R Kuhn, D Pravtcheva, F Ruddle and G Lemke
Molecular Neurobiology Laboratory, Salk Institute, San Diego, California 92138.

We have used somatic cell hybrids to map the gene encoding protein zero (P0), the major structural protein of peripheral myelin. Analysis of Southern blots of DNA obtained from these hybrids allows us to unambiguously assign the P0 gene to mouse chromosome 1. This observation indicates that mutations in the P0 gene do not account for Trembler, a chromosome 11 mutation that specifically affects myelination in the peripheral nervous system.




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