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Journal of Neuroscience, Vol 10, 303-310, Copyright © 1990 by Society for Neuroscience
Microinjection of cocaine into the nucleus accumbens elicits locomotor activation in the rat
JM Delfs, L Schreiber and AE Kelley
Department of Psychology, Harvard University, Cambridge, Massachusetts 02138.
Cocaine is believed to exert its psychostimulant effects through activation
of the mesocorticolimbic system. Although the nucleus accumbens, in
particular, has been hypothesized as the site of action of cocaine's
stimulating effects, there is no direct evidence that microinjection of
cocaine into this region produces behavioral activation. The present
experiments investigated the locomotor response to microinjection of
cocaine (0, 10, 30, 100 micrograms/0.5 microliter) into the nucleus
accumbens in rats. Cocaine elicited a pronounced, dose- dependent motor
activation of approximately 60 min duration. This stimulant effect was
blocked by prior administration of a dopamine (DA) receptor antagonist,
cis-flupenthixol. The response to cocaine was differentiated from nucleus
accumbens microinjections of procaine and lidocaine, compounds that have
potent local anesthetic effects but little affinity for the dopamine-uptake
site. Neither procaine nor lidocaine (0, 10, 30, 100 micrograms/0.5
microliter) had any overall effect, although activity was somewhat
decreased in the initial part of the test session and increased at the end,
relative to control activity. Cocaine injected into the anterior dorsal or
ventrolateral striatum (100 micrograms) also increased motor activity;
procaine and lidocaine had no effect. Cocaine injected into the
ventrolateral striatum significantly increased stereotypy. The amplitude of
motor activation following cocaine injection into nucleus accumbens was
much greater than that elicited at the other striatal sites. Further,
observation of the time course of motor activation following cocaine
injection into the anterior dorsal and ventrolateral striatum suggested
that the motor effect was due to diffusion, most likely to the nucleus
accumbens.(ABSTRACT TRUNCATED AT 250 WORDS)
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