 |
 Previous Article | Next Article 
Journal of Neuroscience, Vol 10, 3479-3493, Copyright © 1990 by Society for Neuroscience
Amygdalar interaction with the mediodorsal nucleus of the thalamus and the ventromedial prefrontal cortex in stimulus-reward associative learning in the monkey
D Gaffan and EA Murray
Department of Experimental Psychology, Oxford University, England.
Cynomolgus monkeys (Macaca fascicularis) were assessed for their ability to
associate visual stimuli with food reward. They learned a series of new
2-choice visual discriminations between colored patterns displayed on a
monitor screen. The feedback for correct choice was the delivery of food.
In order to promote associative learning between the visual stimuli and the
incentive value of the food reward, reward delivery was not accompanied by
any distinctive visual feedback on the display screen. The rate of learning
new problems was assessed before and after surgery in a total of 16
monkeys. Three groups of 3 monkeys received bilaterally symmetrical
ablations in either the amygdala, the mediodorsal nucleus of the thalamus,
or the ventromedial prefrontal cortex. All these groups showed a severe
postoperative learning impairment. Seven other animals were given a
unilateral ablation in 1 of those 3 structures and a second unilateral
ablation, in each case contralateral to and different from the first, in
order to produce 2 groups in which a putative amygdalo-thalamo-prefrontal
pathway had been disconnected by crossed unilateral lesions. One
disconnection group had lesions in the amygdala and ventromedial prefrontal
cortex; the other had lesions in the amygdala and the mediodorsal nucleus
of the thalamus. The disconnection groups showed a significant impairment,
but the effect of the disconnection surgeries was significantly milder than
the effect of any of the 3 bilaterally symmetrical lesions. Therefore,
symmetrical bilateral lesions in either the amygdala, the mediodorsal
nucleus, or the ventromedial prefrontal cortex produce similar impairments
in the present task, implying that these structures are functionally
related to each other; but the relatively mild effect of disconnecting
these structures from each other argues against the hypothesis that they
are serial stages in a single, tightly linked functional pathway.
This article has been cited by other articles:
|
|
|
|
 
A. S. Mitchell, P. G. F. Browning, C. R. E. Wilson, M. G. Baxter, and D. Gaffan
Dissociable Roles for Cortical and Subcortical Structures in Memory Retrieval and Acquisition
J. Neurosci.,
August 20, 2008;
28(34):
8387 - 8396.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
P. G. F. Browning and D. Gaffan
Prefrontal Cortex Function in the Representation of Temporally Complex Events
J. Neurosci.,
April 9, 2008;
28(15):
3934 - 3940.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
A. S. Mitchell and D. Gaffan
The Magnocellular Mediodorsal Thalamus is Necessary for Memory Acquisition, But Not Retrieval
J. Neurosci.,
January 2, 2008;
28(1):
258 - 263.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
A. S. Mitchell, M. G. Baxter, and D. Gaffan
Dissociable Performance on Scene Learning and Strategy Implementation after Lesions to Magnocellular Mediodorsal Thalamic Nucleus
J. Neurosci.,
October 31, 2007;
27(44):
11888 - 11895.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
A. S. Mitchell, P. G. F. Browning, and M. G. Baxter
Neurotoxic Lesions of the Medial Mediodorsal Nucleus of the Thalamus Disrupt Reinforcer Devaluation Effects in Rhesus Monkeys
J. Neurosci.,
October 17, 2007;
27(42):
11289 - 11295.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M. R. Roesch and C. R. Olson
Neuronal Activity in Primate Orbitofrontal Cortex Reflects the Value of Time
J Neurophysiol,
October 1, 2005;
94(4):
2457 - 2471.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M. R. Roesch and C. R. Olson
Impact of Expected Reward on Neuronal Activity in Prefrontal Cortex, Frontal and Supplementary Eye Fields and Premotor Cortex
J Neurophysiol,
September 1, 2003;
90(3):
1766 - 1789.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
A. E. Baldwin, K. Sadeghian, and A. E. Kelley
Appetitive Instrumental Learning Requires Coincident Activation of NMDA and Dopamine D1 Receptors within the Medial Prefrontal Cortex
J. Neurosci.,
February 1, 2002;
22(3):
1063 - 1071.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
D. A. Powell and J. Churchwell
Mediodorsal Thalamic Lesions Impair Trace Eyeblink Conditioning in the Rabbit
Learn. Mem.,
January 1, 2002;
9(1):
10 - 17.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
G. Schoenbaum and B. Setlow
Integrating Orbitofrontal Cortex into Prefrontal Theory: Common Processing Themes across Species and Subdivisions
Learn. Mem.,
May 1, 2001;
8(3):
134 - 147.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
J. H. Kaas and T. A. Hackett
Subdivisions of auditory cortex and processing streams in primates
PNAS,
October 24, 2000;
97(22):
11793 - 11799.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
D. Gaffan and A. Parker
Mediodorsal thalamic function in scene memory in rhesus monkeys
Brain,
April 1, 2000;
123(4):
816 - 827.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
A.C. Roberts and J.D. Wallis
Inhibitory Control and Affective Processing in the Prefrontal Cortex: Neuropsychological Studies in the Common Marmoset
Cereb Cortex,
March 1, 2000;
10(3):
252 - 262.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
J. A. Rosenkranz and A. A. Grace
Modulation of Basolateral Amygdala Neuronal Firing and Afferent Drive by Dopamine Receptor Activation In Vivo
J. Neurosci.,
December 15, 1999;
19(24):
11027 - 11039.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
R. Dias, T. W. Robbins, and A. C. Roberts
Dissociable Forms of Inhibitory Control within Prefrontal Cortex with an Analog of the Wisconsin Card Sort Test: Restriction to Novel Situations and Independence from "On-Line" Processing
J. Neurosci.,
December 1, 1997;
17(23):
9285 - 9297.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
L. Malkova, D. Gaffan, and E. A. Murray
Excitotoxic Lesions of the Amygdala Fail to Produce Impairment in Visual Learning for Auditory Secondary Reinforcement But Interfere with Reinforcer Devaluation Effects in Rhesus Monkeys
J. Neurosci.,
August 1, 1997;
17(15):
6011 - 6020.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
D. A. Powell, B. Maxwell, and J. Penney
Neuronal Activity in the Medial Prefrontal Cortex during Pavlovian Eyeblink and Nictitating Membrane Conditioning
J. Neurosci.,
October 1, 1996;
16(19):
6296 - 6306.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
T. Oyoshi, H. Nishijo, T. Asakura, Y. Takamura, and T. Ono
Emotional and Behavioral Correlates of Mediodorsal Thalamic Neurons during Associative Learning in Rats
J. Neurosci.,
September 15, 1996;
16(18):
5812 - 5829.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
D. Gaffan and A. Parker
Interaction of Perirhinal Cortex with the Fornix-Fimbria: Memory for Objects and ``Object-in-Place'' Memory
J. Neurosci.,
September 15, 1996;
16(18):
5864 - 5869.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
