WWW.JNEUROSCI.ORG
-
The Journal of Neuroscience
QUICK SEARCH:   [advanced]


     
-


HOME  |   SEARCH  |   ARCHIVE  |   SUBSCRIBE  |   CONTACT  |   HELP
This Article
Right arrow Full Text (PDF)
Right arrow Submit an eLetter
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Web of Science (91)
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Grinspan, J. B.
Right arrow Articles by Pleasure, D.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Grinspan, J. B.
Right arrow Articles by Pleasure, D.

 Previous Article  |  Next Article 

Journal of Neuroscience, Vol 10, 1866-1873, Copyright © 1990 by Society for Neuroscience

ARTICLE

Cerebral white matter contains PDGF-responsive precursors to O2A cells

JB Grinspan, JL Stern, SM Pustilnik and D Pleasure
Neurology Research, Children's Hospital, Philadelphia, Pennsylvania 19104.

Cells dissociated from the cerebral white matter of immature rats were maintained in monolayer culture. Treatment with platelet-derived growth factor (PDGF) caused a large increase in the numbers of "O2A" oligodendroglial precursor cells (which bind the monoclonal antibody A2B5) and subsequently in the numbers of galactocerebroside (galC)- positive oligodendroglia. A2B5-negative "pre-O2A cells" in cerebral white matter cultures in which O2A cells and oligodendroglia had been killed by antibody-dependent complement-mediated cytolysis were induced by PDGF to proliferate and to differentiate into O2A cells and subsequently into oligodendroglia and type 2 astroglia. The most mature pre-O2A phenotype in these cultures was a small, round, process-bearing cell which expressed vimentin but not glial fibrillary acidic protein or galC. Cells of this phenotype were not observed upon PDGF treatment of immature rat optic nerve monolayer cultures from which O2A cells and oligodendrocytes had been depleted, and PDGF also failed to elicit the accumulation of O2A cells and oligodendroglia in such cultures.


This article has been cited by other articles:


Home page
 EndocrinologyHome page
D. S. Sharlin, R. Bansal, and R. T. Zoeller
Polychlorinated Biphenyls Exert Selective Effects on Cellular Composition of White Matter in a Manner Inconsistent with Thyroid Hormone Insufficiency
Endocrinology, February 1, 2006; 147(2): 846 - 858.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
N. Gregori, C. Proschel, M. Noble, and M. Mayer-Proschel
The Tripotential Glial-Restricted Precursor (GRP) Cell and Glial Development in the Spinal Cord: Generation of Bipotential Oligodendrocyte-Type-2 Astrocyte Progenitor Cells and Dorsal-Ventral Differences in GRP Cell Function
J. Neurosci., January 1, 2002; 22(1): 248 - 256.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
T. D. Palmer, E. A. Markakis, A. R. Willhoite, F. Safar, and F. H. Gage
Fibroblast Growth Factor-2 Activates a Latent Neurogenic Program in Neural Stem Cells from Diverse Regions of the Adult CNS
J. Neurosci., October 1, 1999; 19(19): 8487 - 8497.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
C. Taveggia, A. Pizzagalli, M. L. Feltri, J. B. Grinspan, J. Kamholz, and L. Wrabetz
MEBA Derepresses the Proximal Myelin Basic Protein Promoter in Oligodendrocytes
J. Biol. Chem., October 16, 1998; 273(42): 27741 - 27748.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
T. Ben-Hur, B. Rogister, K. Murray, G. Rougon, and M. Dubois-Dalcq
Growth and Fate of PSA-NCAM+ Precursors of the Postnatal Brain
J. Neurosci., August 1, 1998; 18(15): 5777 - 5788.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
D. J. Osterhout, S. Ebner, J. Xu, D. M. Ornitz, G. A. Zazanis, and R. D. McKinnon
Transplanted Oligodendrocyte Progenitor Cells Expressing a Dominant-Negative FGF Receptor Transgene Fail to Migrate In Vivo
J. Neurosci., December 1, 1997; 17(23): 9122 - 9132.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
R. Awatramani, S. Scherer, J. Grinspan, E. Collarini, R. Skoff, D. O'Hagan, J. Garbern, and J. Kamholz
Evidence That the Homeodomain Protein Gtx Is Involved in the Regulation of Oligodendrocyte Myelination
J. Neurosci., September 1, 1997; 17(17): 6657 - 6668.
[Abstract] [Full Text] [PDF]

Home page
 JCBHome page
T. Vartanian, A. Goodearl, A. Viehover, and G. Fischbach
Axonal Neuregulin Signals Cells of the Oligodendrocyte Lineage through Activation of HER4 and Schwann Cells through HER2 and HER3
J. Cell Biol., April 7, 1997; 137(1): 211 - 220.
[Abstract] [Full Text] [PDF]

Home page
 Mult SclerHome page
S. Ferraresi, I. Lorenzetti, R. Nemni, J. Kamholz, M. Feltri, and L. Wrabetz
Toward a transgenic mouse model of remyelination
Multiple Sclerosis, April 1, 1997; 3(2): 80 - 83.
[Abstract] [PDF]

Home page
 DevelopmentHome page
K Ono, R Bansal, J Payne, U Rutishauser, and R. Miller
Early development and dispersal of oligodendrocyte precursors in the embryonic chick spinal cord
Development, January 6, 1995; 121(6): 1743 - 1754.
[Abstract] [PDF]


-
-

Home  |   Search  |   Archive  |   Subscribe  |   Contact  |   Help
-
Copyright 2009 by Society for Neuroscience ONLINE ISSN: 1529-2401
-