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Journal of Neuroscience, Vol 10, 1906-1911, Copyright © 1990 by Society for Neuroscience
The amygdala central nucleus and appetitive Pavlovian conditioning: lesions impair one class of conditioned behavior
M Gallagher, PW Graham and PC Holland
Department of Psychology, University of North Carolina, Chapel Hill 27599.
Rats with neurotoxic lesions of the amygdala central nucleus (CN) were
trained using appetitive Pavlovian conditioning procedures. Conditioned
responses (CRs) that are representative of 2 classes of behavior were
monitored. One type of CR resembled the orienting responses that were
elicited by the conditioned stimuli (CSs) prior to pairing with food
reinforcement: the other type of CR resembled the behavior elicited by food
reinforcement itself. Holland (1977, 1984) has referred to these as
CS-generated and unconditioned stimulus (US)-generated CRs, respectively.
During differential conditioning, some lesioned and unlesioned rats
received reinforced presentations of a visual cue and nonreinforced
presentations of an auditory cue, and the others in each lesion condition
received reinforced auditory and nonreinforced visual cue presentations.
Relative to the control group, the CN-lesioned rats were impaired in the
acquisition of CS-generated CRs to both visual and auditory CSs. Orienting
responses and habituation to the CSs were, however, comparable for the
lesion and control groups. Moreover, rats with CN lesions readily acquired
the US-generated CRs. Thus, a specific class of conditioned behavior was
impaired by CN damage. Many studies using aversive Pavlovian procedures
have suggested that CN lesions impair fear conditioning. The present
results suggest another role for CN in the conditioning of
orienting/attentional responses.
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