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Journal of Neuroscience, Vol 10, 1922-1928, Copyright © 1990 by Society for Neuroscience
Serotonin enhances a low-voltage-activated calcium current in rat spinal motoneurons
AJ Berger and T Takahashi
Department of Physiology, Kyoto University Faculty of Medicine, Japan.
Calcium currents and the effects of 5-HT on these currents were
investigated in visually identified motoneurons using whole-cell recording
in the neonatal rat spinal cord slice preparation. In current- clamp
recording, step depolarizations from a holding potential of about -90 mV
produced a low-threshold transient depolarizing response and a
high-threshold long-lasting spike. In voltage-clamp recording, low (LVA)
and high (HVA) voltage-activated Ca2+ currents were recorded in response to
depolarizing voltage steps. Low concentration of Cd2+ (50 microM) did not
reduce the amplitude of the LVA current but markedly diminished the HVA
current. Bath application of 5-HT (10-50 microM) markedly increased the
amplitude of the LVA current without causing a shift in the current
(I)-voltage (V) relation. In contrast, 5-HT did not appreciably affect the
amplitude of the HVA current. We conclude that 5-HT specifically enhances
the LVA Ca2+ current and that this effect together with the previously
reported 5-HT-induced inward current (Takahashi and Berger, 1990), would
facilitate the excitation of motoneurons.
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