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Journal of Neuroscience, Vol 11, 2995-3007, Copyright © 1991 by Society for Neuroscience
Functional specificity of a long-range horizontal connection in cat visual cortex: a cross-correlation study
C Schwarz and J Bolz
Friedrich-Miescher-Labor der Max-Planck-Gesellschaft, Tubingen, Germany.
Anatomical investigations of the visual cortex revealed a regular set of
interlaminar connections and long-range horizontal connections. An
important component of the intrinsic cortical circuit is the projection
from layer 5 to layer 6 over long horizontal distances. Previous work has
shown that when layer 5 is locally inactivated, layer 6 cells lose their
response in a segment of their receptive fields corresponding to the
blocked area in layer 5. It has therefore been proposed that the long
receptive fields characteristic of layer 6 cells might be generated by
concatenating layer 5 cells with similar orientation preferences. In the
present study, we used cross-correlation analysis to examine both source
and target cells of the interlaminar connection from layer 5 to layer 6. We
found correlated firing between cells separated by up to 4.2 mm, the
longest horizontal distance studied. The occurrence of correlated firing
depended on the functional properties and on the topographic position of
the cells in layer 5 and layer 6. Interactions were only observed if the
cells had matching orientation tuning and similar eye preference and if the
layer 5 cells lay within the summation area of the layer 6 cells. Both
simple and complex cells in layer 6 fired in synchrony with layer 5 cells.
In layer 5, mainly standard complex cells, but very few special complex
cells, participated in correlated firing with layer 6 cells. These results
suggest that cells in layer 6 receive their input from cooriented,
coaxially aligned standard complex cells in layer 5. This topographic
arrangement and the length summation properties of standard complex cells
in layer 5 are well suited to generate long receptive fields in layer 6.
Thus, our experiments provide evidence for the functional specialization of
a particular component of cortical circuitry.
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