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Journal of Neuroscience, Vol 11, 1347-1358, Copyright © 1991 by Society for Neuroscience
Relation of cortical cell orientation selectivity to alignment of receptive fields of the geniculocortical afferents that arborize within a single orientation column in ferret visual cortex
B Chapman, KR Zahs and MP Stryker
Department of Physiology, University of California, San Francisco 94143- 0444.
Neurons in the primary visual cortex of higher mammals are arranged in
columns, and the neurons in each column respond best to light-dark borders
of particular orientations. The basis of cortical cell orientation
selectivity is not known. One possible mechanism would be for cortical
cells to receive input from several lateral geniculate nucleus (LGN)
neurons with receptive fields that are aligned in the visual field (Hubel
and Wiesel, 1962). We have investigated the relationship between the
arrangement of the receptive fields of geniculocortical afferents and the
orientation preferences of cortical cells in the orientation columns to
which the afferents provide visual input. Radial microelectrode
penetrations were made into primary visual cortex of anesthetized adult
sable ferrets. Cortical cells were recorded throughout the depth of the
cortex, and their orientation preferences were determined. Cortical cell
responses were then eliminated by superfusion of the cortex with either
kainic acid (Zahs and Stryker, 1988) or muscimol. After the drug treatment,
responses from many single units with distinct receptive fields were
recorded. These responses were presumed to be those of geniculocortical
afferents, because they had the response properties characteristic of LGN
neurons, and because they could be recorded only in cortical layers that
receive geniculate input. In 16 of 18 cases, the afferent receptive fields
recorded in a single penetration covered an elongated region of visual
space. In these penetrations, the best-fit line through the centers of the
afferent receptive fields generally paralleled the preferred orientation of
cortical cells recorded at the same site in cortex. These results are
consistent with the Hubel and Wiesel (1962) model for the construction of
oriented visual cortical receptive fields from geniculate inputs with
aligned receptive fields.
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