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Journal of Neuroscience, Vol 11, 2259-2269, Copyright © 1991 by Society for Neuroscience
Voltage-dependent calcium currents in Purkinje cells from rat cerebellar vermis
LJ Regan
Department of Neurobiology, Harvard Medical School, Boston, Massachusetts 02115.
Whole-cell patch clamp recording was used to characterize calcium currents
in Purkinje cells dissociated from the cerebellar vermis of 1- 3-week
postnatal rats. A subset of Purkinje cells had a low-threshold, transient
current similar to the T-type current in peripheral neurons. All Purkinje
cells had a high-threshold, slowly inactivating current. Only a small
component of the high-threshold current was sensitive to dihydropyridine
(DHP) antagonists or to the dihydropyridine agonist BAY K8644.
omega-Conotoxin had very little effect on the high-threshold current. The
results suggest that these Purkinje cells have at least three types of
calcium channels: T-type channels (present in only a fraction of cells),
DHP-sensitive L-type channels (contributing a small fraction of the
high-threshold current), and a predominant type of high- threshold channel
that is pharmacologically distinct from L-type and N- type channels
characterized in peripheral neurons.
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