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Journal of Neuroscience, Vol 11, 2477-2488, Copyright © 1991 by Society for Neuroscience
Evidence for the ventral origin of oligodendrocyte precursors in the rat spinal cord
BC Warf, J Fok-Seang and RH Miller
Department of Neurosciences, Case Western Reserve University School of Medicine, Cleveland, Ohio 44106.
The neuroepithelial cells of the mammalian neural tube are thought to give
rise to all classes of differentiated neurons and macroglial cells in the
adult CNS. In most cases, the regulation and timing of commitment of
neuroepithelial cells to specific differentiative pathways are unknown. It
has been proposed that in developing spinal cord, the macroglial
cells--astrocytes and oligodendrocytes--arise either by the direct
transformation of radial glial cells in the developing cord or,
alternatively, by the differentiation of distinct precursor cells which
migrate to presumptive white matter from the region of the central canal
during development. In this study, the timing of oligodendrocyte
differentiation in different levels of the spinal cord and the capacity of
specific regions of the spinal cord to give rise to oligodendrocytes at
various ages was tested in vitro. At embryonic day 14, all complete
segments, as well as all ventral regions along the rostral-caudal axis of
the spinal cord, have the capacity for oligodendrogenesis. By contrast,
dorsal regions of the thoracic and lumbar spinal cord do not develop the
capacity for oligodendrogenesis until later in development. The capacity of
dorsal rat spinal cord to give rise to oligodendrocytes appears to be
associated with the ventral- to-dorsal migration of oligodendrocyte
precursors. These observations suggest that commitment to an
oligodendrocyte differentiative pathway appears to occur in a distinct
population of ventrally located glial precursors in the embryonic rat
spinal cord.
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