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Journal of Neuroscience, Vol 12, 180-187, Copyright © 1992 by Society for Neuroscience
Characterization of the integration time for the stabilization of long- term potentiation in area CA1 of the hippocampus
A Colino, YY Huang and RC Malenka
Department of Psychiatry, University of California, San Francisco 94143.
In area CA1 of the hippocampus, synaptic activation of NMDA receptors
during postsynaptic depolarization can generate either a decremental
synaptic potentiation termed short-term potentiation (STP) or stable,
long-term potentiation (LTP). Examining the relationship between these two
forms of synaptic enhancement should provide information about the
intracellular processes responsible for the stabilization of LTP. Using the
hippocampal slice preparation, initial experiments confirmed that STP can
be generated either by a weak tetanus or by pairing a single EPSP with
postsynaptic depolarization. Following the generation of submaximal LTP,
application of a weak, STP-inducing tetanus resulted in STP (not LTP),
suggesting that the processes responsible for stabilizing LTP must be
activated during induction and cannot be accessed at later times. To
determine the interval over which processes activated during STP can be
integrated and result in stable LTP (the "integration time" for the
stabilization of LTP), a fixed number of afferent stimuli were given at
varying intervals (5-60 sec) during postsynaptic depolarization. Using
either extracellular or whole-cell recording, LTP was rarely (11% of
experiments) elicited at 1 min intervals and frequently (76% of
experiments) elicited at 10 sec intervals. These results indicate that
following a single EPSP during postsynaptic depolarization, the processes
responsible for the stabilization of LTP decay significantly within
approximately 1 min, although this value may depend on the level of
activation of the requisite intracellular processes.
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