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Journal of Neuroscience, Vol 12, 356-361, Copyright © 1992 by Society for Neuroscience
Pre- and postsynaptic inhibition by opioids in rat striatum
ZG Jiang and RA North
Vollum Institute, Oregon Health Sciences University, Portland 97201.
The physiological role of opioid peptides in the rat striatum was sought by
intracellular recording in vitro. Excitatory synaptic potentials (mediated
by glutamate or aspartate) and inhibitory synaptic potentials (mediated by
GABA) were isolated pharmacologically and/or by positioning the stimulation
electrode over the external capsule. Opioid agonists and antagonists
selective for mu-, delta-, and kappa-receptors were applied by superfusion.
Two main actions of opioids were observed. First, mu- and delta-selective
opioids presynaptically inhibited the excitatory postsynaptic potential,
whereas only delta-selective opioids decreased the inhibitory synaptic
potential. Second, a small subpopulation of cells (not medium spiny
neurons) were hyperpolarized by delta-selective agonists. The results
indicate that the main action of opioids on striatal neurons is presynaptic
inhibition of the corticostriate excitatory synaptic input.
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