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Journal of Neuroscience, Vol 12, 440-453, Copyright © 1992 by Society for Neuroscience
Distribution and cellular localization of mRNA coding for 5-HT1A receptor in the rat brain: correlation with receptor binding
M Pompeiano, JM Palacios and G Mengod
Sandoz Pharma Limited, Basel, Switzerland.
In order to localize the cells expressing 5-HT1A receptors in the rat
brain, we used in situ hybridization histochemistry to visualize the
distribution of the mRNA coding for 5-HT1A receptors. Oligonucleotides
derived from different parts of the coding region of the rat 5-HT1A
receptor gene were used as hybridization probes. 5-HT1A binding sites were
visualized on consecutive sections by receptor autoradiography using
3H-8-hydroxy-2-(di-n-propylamino)tetralin as ligand. The highest levels of
hybridization were observed in the dorsal raphe nucleus, septum,
hippocampus, entorhinal cortex, and interpeduncular nucleus. Positive
hybridization signals were also present in other areas, such as the
olfactory bulb; cerebral cortex; some thalamic and hypothalamic nuclei;
several nuclei of the brainstem, including all the remaining raphe nuclei,
nucleus of the solitary tract, and nucleus of the spinal tract of the
trigeminus; and the dorsal horn of the spinal cord. The distribution and
abundance of 5-HT1A receptor mRNA in different rat brain areas generally
correlate with those of the binding sites, suggesting that 5-HT1A receptors
are predominantly somatodendritic receptors.
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