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Journal of Neuroscience, Vol 12, 810-817, Copyright © 1992 by Society for Neuroscience
Proctolin activates an inward current whose voltage dependence is modified by extracellular Ca2+
J Golowasch and E Marder
Biology Department, Brandeis University, Waltham, Massachusetts 02254.
The pentapeptide proctolin modulates the activity of the rhythmic pattern
generators in the crustacean stomatogastric nervous system. Proctolin
strongly excites the lateral pyloric and the inferior cardiac neurons of
the stomatogastric ganglion (STG), causing them to fire extended
high-frequency bursts of action potentials (Hooper and Marder, 1987;
Nusbaum and Marder, 1989a,b). We now report that proctolin depolarizes
these cells maximally at membrane potentials close to the threshold for
action potential generation. In voltage clamp, proctolin evokes an inward
current, carried at least partially by Na+, that shows strong outward
rectification. Removal of extracellular Ca2+ markedly increases the
amplitude of the proctolin-evoked current and linearizes its
current-voltage curve. The properties of the proctolin current make it
ideally suited to contribute to the activity-dependent modulation of the
pyloric network of the STG.
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