 |
 Previous Article | Next Article 
Journal of Neuroscience, Vol 12, 2516-2522, Copyright © 1992 by Society for Neuroscience
A nonphotic stimulus causes instantaneous phase advances of the light- entrainable circadian oscillator of the Syrian hamster but does not induce the expression of c-fos in the suprachiasmatic nuclei
S Mead, FJ Ebling, ES Maywood, T Humby, J Herbert and MH Hastings
Department of Anatomy, University of Cambridge, United Kingdom.
The study investigated whether nonphotic cues that alter the phase of overt
circadian rhythms do so by causing instantaneous shifts in the underlying,
light-sensitive clock. Wheel-running activity in Syrian hamsters was
studied under free-running conditions of constant dim red light as an overt
marker of circadian phase, the daily onset of activity being defined as
circadian time 12 (CT 12). Exposure to a 15 min pulse of bright light at CT
12.20 caused a phase delay in activity onset, whereas pulses delivered at
CT 11.20 had no effect upon the overt rhythm. Correlated with their effect
on behavior, light pulses delivered at CT 12.20 induced expression of
c-fos-like immunoreactivity in the retinorecipient regions of the
suprachiasmatic nuclei of the hypothalamus (SCN), whereas pulses delivered
at CT 11.20 had no effect upon the expression of c-fos. Expression of this
immediate-early gene therefore provided a second marker of circadian phase,
because its induction by light is closely correlated with the onset of
subjective night (CT 12). To establish a suitable protocol for nonphotic
shifts of the activity rhythm, animals were handled and received a
subcutaneous injection of saline at different circadian phases. Injections
at CT 8 or CT10 caused an immediate bout of wheel-running activity, and a
consequent phase advance in the activity rhythm as assessed by the earlier
onsets of activity in successive days. Handling and injections at other
circadian phases were without effect. Despite shifting the overt rhythm,
these procedures at CT 10 did not lead to the expression of c-fos in the
SCN.(ABSTRACT TRUNCATED AT 250 WORDS)
This article has been cited by other articles:
|
|
|
|
 
R. Salgado-Delgado, M. Angeles-Castellanos, N. Saderi, R. M. Buijs, and C. Escobar
Food Intake during the Normal Activity Phase Prevents Obesity and Circadian Desynchrony in a Rat Model of Night Work
Endocrinology,
March 1, 2010;
151(3):
1019 - 1029.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
H.-Y. M. Cheng, H. Dziema, J. Papp, D. P. Mathur, M. Koletar, M. R. Ralph, J. M. Penninger, and K. Obrietan
The Molecular Gatekeeper Dexras1 Sculpts the Photic Responsiveness of the Mammalian Circadian Clock
J. Neurosci.,
December 13, 2006;
26(50):
12984 - 12995.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
R. E. Mistlberger, M. C. Antle, I. C. Webb, M. Jones, J. Weinberg, and M. S. Pollock
Circadian clock resetting by arousal in Syrian hamsters: the role of stress and activity
Am J Physiol Regulatory Integrative Comp Physiol,
October 1, 2003;
285(4):
R917 - R925.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
D. C. Holley, C. W. DeRoshia, M. M. Moran, and C. E. Wade
Chronic centrifugation (hypergravity) disrupts the circadian system of the rat
J Appl Physiol,
September 1, 2003;
95(3):
1266 - 1278.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M. C. Antle and R. E. Mistlberger
Circadian Clock Resetting by Sleep Deprivation without Exercise in the Syrian Hamster
J. Neurosci.,
December 15, 2000;
20(24):
9326 - 9332.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
K. Horikawa, S.-i. Yokota, K. Fuji, M. Akiyama, T. Moriya, H. Okamura, and S. Shibata
Nonphotic Entrainment by 5-HT1A/7 Receptor Agonists Accompanied by Reduced Per1 and Per2 mRNA Levels in the Suprachiasmatic Nuclei
J. Neurosci.,
August 1, 2000;
20(15):
5867 - 5873.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
E. S. Maywood, N. Mrosovsky, M. D. Field, and M. H. Hastings
Rapid down-regulation of mammalian Period genes during behavioral resetting of the circadian clock
PNAS,
December 21, 1999;
96(26):
15211 - 15216.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
E. G. Marchant and L. P. Morin
The Hamster Circadian Rhythm System Includes Nuclei of the Subcortical Visual Shell
J. Neurosci.,
December 1, 1999;
19(23):
10482 - 10493.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
S. Benloucif, M. I. Masana, K. Yun, and M. L. Dubocovich
Interactions between Light and Melatonin on the Circadian Clock of Mice
J Biol Rhythms,
August 1, 1999;
14(4):
281 - 289.
[Abstract]
[PDF]
|
|
|
|
|
|
|
J. D. Best, E. S. Maywood, K. L. Smith, and M. H. Hastings
Rapid Resetting of the Mammalian Circadian Clock
J. Neurosci.,
January 15, 1999;
19(2):
828 - 835.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
K. M. Ogilvie, S. Lee, and C. Rivier
Divergence in the Expression of Molecular Markers of Neuronal Activation in the Parvocellular Paraventricular Nucleus of the Hypothalamus Evoked by Alcohol Administration via Different Routes
J. Neurosci.,
June 1, 1998;
18(11):
4344 - 4352.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
A. Sumova and H. Illnerova
Photic resetting of intrinsic rhythmicity of the rat suprachiasmatic nucleus under various photoperiods
Am J Physiol Regulatory Integrative Comp Physiol,
March 1, 1998;
274(3):
R857 - R863.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
S. Benloucif and M. L. Dubocovich
Melatonin and Light Induce Phase Shifts of Circadian Activity Rhythms in the C3H/HeN Mouse
J Biol Rhythms,
June 1, 1996;
11(2):
113 - 125.
[Abstract]
[PDF]
|
|
|
|
|
|
|
W. J. Schwartz, R. V. Peters, N. Aronin, and M. R. Bennett
Unexpected c-fos Gene Expression in the Suprachiasmatic Nucleus of Mice Entrained to a Skeleton Photoperiod
J Biol Rhythms,
March 1, 1996;
11(1):
35 - 44.
[Abstract]
[PDF]
|
|
|
|
|
|
|
C. S. Colwell, C. M. Kaufman, M. Menaker, and M. R. Ralph
Light-Induced Phase Shifts and Fos Expression in the Hamster Circadian System: The Effects of Anesthetics
J Biol Rhythms,
October 1, 1993;
8(3):
179 - 188.
[Abstract]
[PDF]
|
|
|
|
