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Journal of Neuroscience, Vol 13, 1097-1105, Copyright © 1993 by Society for Neuroscience
Increased plasma ACTH responses to stress in nonhandled compared with handled rats require basal levels of corticosterone and are associated with increased levels of ACTH secretagogues in the median eminence
V Viau, S Sharma, PM Plotsky and MJ Meaney
Developmental Neuroendocrinology Laboratory, Douglas Hospital Research Center, Montreal, Canada.
Postnatal handling of rat pups is known to alter permanently
hypothalamic-pituitary-adrenal (HPA) responses to a wide variety of
stressors. As adults, handled (H) and nonhandled (NH) animals also differ
in sensitivity to the delayed negative-feedback effects of glucocorticoids
on stress-induced HPA activity. However, it is not understood how handling
alters neuroendocrine responses to stressful stimuli, and how differences
in feedback sensitivity might account for changes in HPA activity both
during and following stress. In the present studies, plasma ACTH responses
to both restraint and ether stress were significantly greater in NH
compared with H animals. Administration of 100 micrograms/kg corticosterone
(B) immediately prior to restraint stress significantly decreased
subsequent plasma ACTH responses to restraint to the same extent in H and
NH animals, suggesting that H and NH animals do not differ in
glucocorticoid fast feedback. H and NH animals adrenalectomized (ADX) 5 d
prior to testing did not differ in plasma ACTH responses to restraint
stress, demonstrating that the differences between the groups are dependent
upon the presence of circulating B. However, the handling effect was
apparent in ADX animals provided with a low level of B replacement
(approximately 5-6 micrograms/dl). B replacement significantly decreased
plasma ACTH levels under both basal conditions and in response to restraint
stress in H/ADX rats. In contrast, although B replacement also decreased
basal ACTH levels in ADX/NH rats, there were no differences in plasma ACTH
responses to restraint between NH/ADX and NH/ADX+B animals.(ABSTRACT
TRUNCATED AT 250 WORDS)
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