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Journal of Neuroscience, Vol 13, 1120-1137, Copyright © 1993 by Society for Neuroscience
Two input systems for body representations in the primate striatal matrix: experimental evidence in the squirrel monkey
AW Flaherty and AM Graybiel
Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge 02139.
The striatum is important in basal ganglia motor control and movement
disorders. In this study we demonstrate the existence of two distinct
sensorimotor cortical input systems to the striatum of the squirrel monkey.
The first is a group of discrete zones in the extrastriosomal matrix of the
putamen ("matrisomes") that receive somatotopically organized projections
from both the body map in ipsilateral primary motor cortex (MI) and maps in
ipsilateral primary somatosensory cortex (SI). The second system is a group
of matrisomes in largely different locations that receive somatotopically
organized inputs from contralateral MI but not SI. Intracortical
microstimulation and multiunit recording were used to guide deposits of
multiple anterograde tracers in MI and SI. Striosome/matrix architecture
was demonstrated by enkephalin immunohistochemistry. We found that inputs
from regions of ipsilateral MI and SI that represented the same body parts
sent projections to the same matrisomes of the ipsilateral putamen.
Contralateral MI sent its strongest inputs to matrisomes that tended to
interdigitate with those receiving inputs from ipsilateral SI and MI,
except the contralateral MI face region, which sent projections that
overlapped those from the ipsilateral MI face region. MI regions
representing axial body parts (trunk and face) sent stronger
representations to the contralateral putamen than did those representing
distal parts (hand and foot). SI sent no contralateral projection. Thus,
with the exception of the face representation, inputs from contralateral
and ipsilateral body representations may alternate in the primate striatal
matrix, an arrangement reminiscent of the alternating ocular dominance
columns in visual cortex. Ipsilateral SI and MI and contralateral MI all
innervated matrisomes intermingled with striosomes and with matrisomes not
receiving sensorimotor cortical input. The patchiness of these maps is thus
unlike the smoother somatotopic maps of sensorimotor cortex, and is also
unlike the fractured somatotopy reported for the cerebellum.
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