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Journal of Neuroscience, Vol 13, 875-893, Copyright © 1993 by Society for Neuroscience
Coexpression of mRNAs for NGF, BDNF, and NT-3 in the cardiovascular system of the pre- and postnatal rat
IA Scarisbrick, EG Jones and PJ Isackson
Department of Anatomy, University of California, Irvine 92717.
The expression of NGF, brain-derived neurotrophic factor (BDNF) and
neurotrophin-3 (NT-3) mRNAs was examined in whole rat embryos and in the
heart and great vessels of postnatal and adult rats, using in situ
hybridization of cRNA probes. The patterns of expression were correlated
with innervation patterns as revealed by immunostaining for neural cell
adhesion molecule (NCAM) and with the HNK-1 antibody, which demonstrates
derivatives of the neural crest. The patterns of neurotrophin mRNA
localization were different from those of mRNAs for the
low-molecular-weight NGF receptor. Hybridization indicating the presence of
mRNAs for all three neurotrophins is particularly prominent within the
tunica media of the aorta, pulmonary, and other major elastic arteries of
the thorax and abdomen and is first observed on embryonic day 13 (E13) when
innervation is being established and rises to maximum by E15. In the fetus,
there is little or no detectable expression in the CNS or PNS. NT-3
expression in the vessels is relatively constant and high from embryonic to
adult stages, while levels of BDNF increase and those of NGF decrease over
the same time course. During the fetal period, hybridization in the heart
is absent. In the postnatal period, additional label becomes detectable in
the coronary arteries but not in the walls of the atria or ventricles,
other than at the base of the aorta and pulmonary trunk.(ABSTRACT TRUNCATED
AT 250 WORDS)
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