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Journal of Neuroscience, Vol 13, 894-899, Copyright © 1993 by Society for Neuroscience
Excitation of rat locus coeruleus neurons by adenosine 5'-triphosphate: ionic mechanism and receptor characterization
KZ Shen and RA North
Vollum Institute, Oregon Health Sciences University, Portland 97201.
ATP and several congeners were applied to locus coeruleus neurons in slices
cut from rat pons. Whole-cell recording of membrane current showed that ATP
caused an inward current at -60 mV. Effective concentrations (applied by
superfusion) were 3-300 microM, and the peak current was about 150 pA at
-60 mV. 2-Methylthioadenosine 5'- triphosphate was slightly more potent
than ATP, adenosine 5'- diphosphate was about equipotent with ATP,
alpha,beta-methylene adenosine 5'-triphosphate was slightly less potent
than ATP, and beta,gamma'-methylene adenosine 5'-triphosphate and adenosine
5'- monophosphate had little or no effect. Adenosine (100 microM) caused
small outward currents (40 pA). By changing the ionic composition of the
pipette and extracellular solution, it was shown that the inward current
resulted from both an increase in conductance to sodium ions and a
reduction in conductance to potassium ions. It is concluded that rat locus
coeruleus neurons express P2 purinoceptors, activation of which depolarizes
the cells predominantly by increasing a conductance that allows sodium ions
to enter the cell.
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