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Journal of Neuroscience, Vol 13, 900-913, Copyright © 1993 by Society for Neuroscience
Responses of monkey dopamine neurons to reward and conditioned stimuli during successive steps of learning a delayed response task
W Schultz, P Apicella and T Ljungberg
Institut de Physiologie, Universite de Fribourg, Switzerland.
The present investigation had two aims: (1) to study responses of dopamine
neurons to stimuli with attentional and motivational significance during
several steps of learning a behavioral task, and (2) to study the activity
of dopamine neurons during the performance of cognitive tasks known to be
impaired after lesions of these neurons. Monkeys that had previously
learned a simple reaction time task were trained to perform a spatial
delayed response task via two intermediate tasks. During the learning of
each new task, a total of 25% of 76 dopamine neurons showed phasic
responses to the delivery of primary liquid reward, whereas only 9% of 163
neurons responded to this event once task performance was established. This
produced an average population response during but not after learning of
each task. Reward responses during learning were significantly more
numerous and pronounced in area A10, as compared to areas A8 and A9.
Dopamine neurons also showed phasic responses to the two conditioned
stimuli. These were the instruction cue, which was the first stimulus in
each trial and indicated the target of the upcoming arm movement (58% of 76
neurons during and 44% of 163 neurons after learning), and the trigger
stimulus, which was a conditioned incentive stimulus predicting reward and
eliciting a saccadic eye movement and an arm reaching movement (38% of
neurons during and 40% after learning). None of the dopamine neurons showed
sustained activity in the delay between the instruction and trigger stimuli
that would resemble the activity of neurons in dopamine terminal areas,
such as the striatum and frontal cortex. Thus, dopamine neurons respond
phasically to alerting external stimuli with behavioral significance whose
detection is crucial for learning and performing delayed response tasks.
The lack of sustained activity suggests that dopamine neurons do not encode
representational processes, such as working memory, expectation of external
stimuli or reward, or preparation of movement. Rather, dopamine neurons are
involved with transient changes of impulse activity in basic attentional
and motivational processes underlying learning and cognitive behavior.
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|
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|
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|
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|
|
|
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|
|
|
|
|
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|
|
|
|
|
|
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|
|
|
|
|
|
|
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|
|
|
|
|
|
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|
|
|
|
|
|
|
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|
|
|
|
|
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|
|
|
|
|
|
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|
|
|
|
|
|
|
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|
|
|
|
|
|
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|
|
|
|
|
|
|
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[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
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[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
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[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
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[Full Text]
[PDF]
|
|
|
|
|
|
|
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March 21, 2003;
299(5614):
1898 - 1902.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
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February 4, 2003;
100(3):
1405 - 1408.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
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February 1, 2003;
13(2):
123 - 135.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
P. O'Donnell, B. L. Lewis, D. R. Weinberger, and B. K. Lipska
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September 1, 2002;
12(9):
975 - 982.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
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J. Neurosci.,
July 15, 2002;
22(14):
6247 - 6253.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
D. L. Due, S. A. Huettel, W. G. Hall, and D. C. Rubin
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June 1, 2002;
159(6):
954 - 960.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
V. Bassareo, M. A. De Luca, and G. Di Chiara
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J. Neurosci.,
June 1, 2002;
22(11):
4709 - 4719.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
A. E. Baldwin, K. Sadeghian, and A. E. Kelley
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J. Neurosci.,
February 1, 2002;
22(3):
1063 - 1071.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
Y. Takikawa, R. Kawagoe, and O. Hikosaka
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J Neurophysiol,
January 1, 2002;
87(1):
508 - 515.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
T. Suzuki, M. Miura, K.-y. Nishimura, and T. Aosaki
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J. Neurosci.,
September 1, 2001;
21(17):
6492 - 6501.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
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August 1, 2001;
7(4):
293 - 302.
[Abstract]
[PDF]
|
|
|
|
|
|
|
G. S. Berns, S. M. McClure, G. Pagnoni, and P. R. Montague
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J. Neurosci.,
April 15, 2001;
21(8):
2793 - 2798.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
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April 1, 2001;
124(4):
784 - 792.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
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Discharge Profiles of Ventral Tegmental Area GABA Neurons during Movement, Anesthesia, and the Sleep-Wake Cycle
J. Neurosci.,
March 1, 2001;
21(5):
1757 - 1766.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
B. L. Lewis and P. O'Donnell
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December 1, 2000;
10(12):
1168 - 1175.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
C. W. Bradberry
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J. Neurosci.,
September 15, 2000;
20(18):
7109 - 7115.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
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July 1, 2000;
80(3):
953 - 978.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
A. Kulla and D. Manahan-Vaughan
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Cereb Cortex,
June 1, 2000;
10(6):
614 - 620.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
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J. Neurosci.,
May 15, 2000;
20(10):
3874 - 3883.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
A. Handel and P. W. Glimcher
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J Neurophysiol,
May 1, 2000;
83(5):
3042 - 3048.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
L. Tremblay and W. Schultz
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J Neurophysiol,
April 1, 2000;
83(4):
1864 - 1876.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
S. N. Haber, J. L. Fudge, and N. R. McFarland
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J. Neurosci.,
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20(6):
2369 - 2382.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
C. D. Fiorillo and J. T. Williams
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March 1, 2000;
83(3):
1307 - 1314.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
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March 1, 2000;
83(3):
1733 - 1750.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
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March 1, 2000;
10(3):
272 - 283.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
W. Schultz
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December 1, 1999;
14(6):
249 - 255.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
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December 1, 1999;
19(23):
10502 - 10511.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
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September 1, 1999;
5(5):
283 - 294.
[Abstract]
[PDF]
|
|
|
|
|
|
|
D. Durstewitz, M. Kelc, and O. Gunturkun
A Neurocomputational Theory of the Dopaminergic Modulation of Working Memory Functions
J. Neurosci.,
April 1, 1999;
19(7):
2807 - 2822.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
N. R. Richardson and A. Gratton
Changes in Medial Prefrontal Cortical Dopamine Levels Associated with Response-Contingent Food Reward: An Electrochemical Study in Rat
J. Neurosci.,
November 1, 1998;
18(21):
9130 - 9138.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
J. R. Hollerman, L. Tremblay, and W. Schultz
Influence of Reward Expectation on Behavior-Related Neuronal Activity in Primate Striatum
J Neurophysiol,
August 1, 1998;
80(2):
947 - 963.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
L. Tremblay, J. R. Hollerman, and W. Schultz
Modifications of Reward Expectation-Related Neuronal Activity During Learning in Primate Striatum
J Neurophysiol,
August 1, 1998;
80(2):
964 - 977.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
U. Muller, D. Y. von Cramon, and S. Pollmann
D1- Versus D2-Receptor Modulation of Visuospatial Working Memory in Humans
J. Neurosci.,
April 1, 1998;
18(7):
2720 - 2728.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
N. A. Otmakhova and J. E. Lisman
D1/D5 Dopamine Receptors Inhibit Depotentiation at CA1 Synapses via cAMP-Dependent Mechanism
J. Neurosci.,
February 15, 1998;
18(4):
1270 - 1279.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
J. J. Kim, D. J. Krupa, and R. F. Thompson
Inhibitory Cerebello-Olivary Projections and Blocking Effect in Classical Conditioning
Science,
January 23, 1998;
279(5350):
570 - 573.
[Abstract]
[Full Text]
|
|
|
|
|
|
|
G. Di Chiara
A motivational learning hypothesis of the role of mesolimbic dopamine in compulsive drug use
J Psychopharmacol,
January 1, 1998;
12(1):
54 - 67.
[Abstract]
[PDF]
|
|
|
|
|
|
|
C. MISSALE, S. R. NASH, S. W. ROBINSON, M. JABER, and M. G. CARON
Dopamine Receptors: From Structure to Function
Physiol Rev,
January 1, 1998;
78(1):
189 - 225.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
S. Dehaene and J.-P. Changeux
A hierarchical neuronal network for planning behavior
PNAS,
November 25, 1997;
94(24):
13293 - 13298.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
A. E. Kelley, S. L. Smith-Roe, and M. R. Holahan
Response-reinforcement learning is dependent on N-methyl-D-aspartate receptor activation in the nucleus accumbens core
PNAS,
October 28, 1997;
94(22):
12174 - 12179.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
F. X. Castellanos
Toward a Pathophysiology of Attention-Deficit/Hyperactivint Disorder
Clinical Pediatrics,
July 1, 1997;
36(7):
381 - 393.
[Abstract]
[PDF]
|
|
|
|
|
|
|
W. Schultz, P. Dayan, and P. R. Montague
A Neural Substrate of Prediction and Reward
Science,
March 14, 1997;
275(5306):
1593 - 1599.
[Abstract]
[Full Text]
|
|
|
|
|
|
|
R. M. Carelli, M. Wolske, and M. O. West
Loss of Lever Press-Related Firing of Rat Striatal Forelimb Neurons after Repeated Sessions in a Lever Pressing Task
J. Neurosci.,
March 1, 1997;
17(5):
1804 - 1814.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
V. Bassareo and G. Di Chiara
Differential Influence of Associative and Nonassociative Learning Mechanisms on the Responsiveness of Prefrontal and Accumbal Dopamine Transmission to Food Stimuli in Rats Fed Ad Libitum
J. Neurosci.,
January 15, 1997;
17(2):
851 - 861.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
N. R. Richardson and A. Gratton
Behavior-Relevant Changes in Nucleus Accumbens Dopamine Transmission Elicited by Food Reinforcement: An Electrochemical Study in Rat
J. Neurosci.,
December 15, 1996;
16(24):
8160 - 8169.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
N. A. Otmakhova and J. E. Lisman
D1/D5 Dopamine Receptor Activation Increases the Magnitude of Early Long-Term Potentiation at CA1 Hippocampal Synapses
J. Neurosci.,
December 1, 1996;
16(23):
7478 - 7486.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
S. A. Deadwyler and R. E. Hampson
ENHANCED PERSPECTIVE: Ensemble Activity and Behavior--What's the Code?
Science,
November 24, 1995;
270(5240):
1316 - 1316.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
A. Graybiel, T Aosaki, A. Flaherty, and M Kimura
The basal ganglia and adaptive motor control
Science,
September 23, 1994;
265(5180):
1826 - 1831.
[Abstract]
[PDF]
|
|
|
|
|
|
|
T Aosaki, A. Graybiel, and M Kimura
Effect of the nigrostriatal dopamine system on acquired neural responses in the striatum of behaving monkeys
Science,
July 15, 1994;
265(5170):
412 - 415.
[Abstract]
[PDF]
|
|
|
|
|
