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Journal of Neuroscience, Vol 13, 914-923, Copyright © 1993 by Society for Neuroscience
Corticosteroids regulate brain hippocampal 5-HT1A receptor mRNA expression
DT Chalmers, SP Kwak, A Mansour, H Akil and SJ Watson
Mental Health Research Institute, University of Michigan, Ann Arbor 48109.
Using in situ hybridization techniques, the expression of 5-HT1A receptor
mRNA was measured within the hippocampal formation after bilateral
adrenalectomy (ADX). After 24 hr ADX, 5-HT1A receptor mRNA expression was
significantly increased in all hippocampal subfields in ADX animals
relative to sham-operated controls (SHAM). The magnitude of the increase
was most pronounced within CA2 (127%) and CA3/4 (94%)- subfields of dorsal
hippocampus, intermediate in the dentate gyrus (73%), and least within CA1
(60%). Administration of exogenous corticosterone (CORT) at the time of ADX
maintained the level of 5-HT1A receptor mRNA expression within the range of
SHAM animals. In vitro receptor autoradiographic analysis of 5-HT1A
receptors in adjacent sections from the same animals indicated a
simultaneous increase in 5- HT1A binding throughout the hippocampus in
response to ADX. 5-HT1A binding increased to a similar extent
(approximately 30%) in CA subfields and dentate gyrus but remained within
SHAM levels in CORT- replaced animals. 5-HT1A receptor mRNA levels were
also increased in hippocampal subregions of 1 week ADX animals relative to
SHAM animals. Within both CA1 and CA2 subfields, the increments were
approximately double those observed after 1 d ADX. 5-HT1A receptor binding
was increased in every hippocampal subfield to a similar extent as that
observed after 1 d ADX. Increases in both 5-HT1A receptor mRNA expression
and 5-HT1A receptor binding were preventable by administration of exogenous
CORT at the time of ADX. Hippocampal 5-HT1C receptor mRNA and D1 receptor
mRNA expression were not significantly altered by either acute or chronic
ADX treatment. These data indicate that adrenal steroids may selectively
regulate hippocampal 5-HT1A receptors at the level of 5-HT1A receptor mRNA
expression.
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